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    What is Cefixime / Clavulanic Acid?

    Cefixime / Clavulanic Acid is used for Sinusitis, Bacterial infections, Urinary tract infections, Otitis media, Pharyngitis and tonsillitis, Chronic bronchitis exacerbation, Gonorrhea, Lower respiratory tract infections, Skin and skin structure infections and other conditions. This salt combination may also be used for purposes not listed in this medication guide. Detailed information related to Cefixime / Clavulanic Acid's uses, side-effects, reviews, questions, interactions, and precautions is as follows:

    Cefixime / Clavulanic Acid Uses

    Cefixime / Clavulanic Acid is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
    References: 1, 2
    Learn more: Uses

    Cefixime / Clavulanic Acid - Side-effects

    The following is a list of possible side-effects that may occur in medicines that contain Cefixime / Clavulanic Acid. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
    If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.
    References: 1, 2
    Learn more: Side-effects

    Cefixime / Clavulanic Acid Working, Mechanism of Action and Pharmacology

    Cefixime / Clavulanic Acid improves the patient's condition by performing the following functions:
    References: 1, 2

    Cefixime / Clavulanic Acid - Precautions & How to Use

    Before using Cefixime / Clavulanic Acid, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
    • Clostridium difficile associated diarrhea
    • Concomitant use of anticoagulants
    • Diarrhea is a common problem
    • Hepatic dysfunction
    • Hypersensitivity to penicillins
    • If the drug format is suspension, keep it refrigerated and shake well before using
    • If you develop bloody or watery diarrhea contact your doctor immedately
    • Inform your doctor if you have had allergic reactions to penicillins or other cephalosporins in the past
    • It is important that you finish the entire course as prescribed
    • It may reduce the effect of oral contraceptives
    References: 1, 1, 2, 2

    Cefixime / Clavulanic Acid - Drug Interactions

    If you use other drugs or over the counter products at the same time, the effects of Cefixime / Clavulanic Acid may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Cefixime / Clavulanic Acid may interact with the following drugs and products:
    • Allopurinol
    • Anticoagulants
    • Carbamazepine
    • Oral contraceptives
    • Probenecid
    • Warfarin
    References: 1, 2
    Learn more: Interactions

    Cefixime / Clavulanic Acid - Contraindications

    Hypersensitivity to Cefixime / Clavulanic Acid is a contraindication. In addition, Cefixime / Clavulanic Acid should not be used if you have the following conditions:
    • Clostridium difficile infection
    • History of cholestatic jaundice or hepatic dysfunction associated with Amoxicillin and Clavulanate
    • Hypersensitivity to cephalosporins
    • Penicillin hypersensitivity
    • Pseudomembranous colitis
    • Seizure caused by drug
    References: 1, 2
    Learn more: Contraindications

    Cefixime / Clavulanic Acid - Frequently asked Questions

    • Is Cefixime / Clavulanic Acid safe to consume or apply when pregnant?
      • Cefixime: Yes
      • Clavulanic Acid: Please consult with your doctor for case-specific recommendations.
      References: 1 2
    • Is Cefixime / Clavulanic Acid safe while breastfeeding?
      • Cefixime: No
      • Clavulanic Acid: Please discuss the risks and benefits with your doctor.
      References: 1 2
    • Can Cefixime / Clavulanic Acid be used for sinusitis and bacterial infections?
      Yes, sinusitis and bacterial infections are among the most common reported uses for Cefixime / Clavulanic Acid. Please do not use Cefixime / Clavulanic Acid for sinusitis and bacterial infections without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Cefixime / Clavulanic Acid.
    • Is it safe to drive or operate heavy machinery when consuming?
      If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Cefixime / Clavulanic Acid medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Cefixime / Clavulanic Acid. Always consult with your doctor for recommendations specific to your body and health conditions.
    • Is this medicine or product addictive or habit forming?
      Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.
    • Can it be stopped immediately or do I have to slowly ween off consumption?
      Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

    Other important Information on Cefixime / Clavulanic Acid

    Missing a dose

    In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
    References: 3, 4, 5, 6

    Overdosage of Cefixime / Clavulanic Acid

    • Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Cefixime / Clavulanic Acid, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
    • Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
    • Please consult your physician or pharmacist or product package for more information.
    References: 7, 8, 9

    Storage of Cefixime / Clavulanic Acid

    • Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
    • Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Cefixime / Clavulanic Acid.
    References: 10, 11, 12, 13

    Expired Cefixime / Clavulanic Acid

    • Taking a single dose of expired Cefixime / Clavulanic Acid is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
    References: 14, 15

    Dosage Information

    Please consult your physician or pharmacist or refer to product package.

    References

    1. DailyMed LABEL: CEFIXIME- cefixime powder, for suspension - Accessed: October 12, 2016.
    2. Accessed on 11/06/2016. DailyMed LABEL: AMOXICILLIN AND CLAVULANATE POTASSIUM- amoxicillin and clavulanate potassium powder, for suspension - Accessed: October 12, 2016.
    3. - Accessed: July 14, 2016.
    4. - Accessed: July 3, 2016.
    5. Cancer.Net (2014). - Accessed: July 3, 2016.
    6. Schachter, S.C., Shafer, P. O. &; Sirven, J.I. (2013). - Accessed: May 28, 2016.
    7. National Institute of Drug Abuse (2010). - Accessed: July 21, 2016.
    8. eMedicinehealth (2016). - Accessed: July 21, 2016.
    9. Centers for Disease Control and Prevention (2010). - Accessed: July 21, 2016.
    10. Centers for Disease Control and Prevention. December 12, 2011. - Accessed: June 10, 2016.
    11. The Center for Improving Medication Management and the National Council on Patient Information and Education. - Accessed: June 10, 2016.
    12. U.S. Food and Drug Administration. December 24, 2013. - Accessed: June 10, 2016.
    13. World Health Organization: - Accessed: July 1, 2016.
    14. Lyon, R. C., Taylor, J. S., Porter, D. A., et al. (2006) Stability profiles of drug products extended beyond labeled expiration dates. Journal of Pharmaceutical Sciences; 95:1549-60 - Accessed: July 3, 2016.
    15. Harvard Medical School (2016). - Accessed: May 1, 2016.

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    Last updated date

    This page was last updated on 11/04/2017.
    This page provides information for Cefixime / Clavulanic Acid in English.
    Read Reviews » Cefixime / Clavulanic Acid

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