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Wednesday, January 03, 2018 -- Scientists report that they have discovered an ion channel structure that could lead to new approaches to the treatment for kidney stones. The team, which published its study (“Structural Basis of TRPV5 Channel Inhibition by Econazole Revealed by Cryo-EM”) in Nature Structural and Molecular Biology, described atomic-level details of the protein that serves as a passageway for calcium across kidney cell membranes. “The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly selective for Ca 2+, that is present primarily at the apical membrane of distal tubule epithelial cells in the kidney and plays a key role in Ca 2+  reabsorption. Here we present the

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