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    Friday, May 25, 2018 -- According to results from the Annual Report to the Nation on the Status of Cancer, cancer incidence rates have declined in men while remaining stable in women. Additionally, there have been significant declines in cancer death rates, but differences between race and ethnic groups remain.

    Thursday, May 24, 2018 -- Ribociclib plus endocrine therapy improved progression-free survival compared with placebo plus endocrine therapy, and had a manageable safety profile in patients with premenopausal, HR-positive, HER2-negative, advanced breast cancer. The combination could represent a new first-line treatment option for these patients.

    Thursday, May 24, 2018 -- Addition of mitoxantrone plus prednisone to adjuvant androgen-deprivation therapy (ADT), which is hypothesised to reduce mortality in patients with high-risk prostate cancer after radical prostatectomy, does not improve overall survival, according to the results of a recent study.

    Thursday, May 24, 2018 -- Women with metastatic, triple-negative breast cancer who have BRCA1 or BRCA2 mutations are more likely to respond to carboplatin as docetaxel, according to a new study.

    Thursday, May 24, 2018 -- Tucatinib in combination with capecitabine and trastuzumab had acceptable toxicity and showed preliminary anti-tumour activity. Validation of the current study results will be determined in the double-blinded randomised study, HER2CLIMB (ONT-380-206; NCT02614794).

    Thursday, May 24, 2018 -- The skin of children with early-onset atopic dermatitis exhibits significantly different phenotypes when compared with the skin of adults with a long-standing history with the disease, according to research published in The Journal of Allergy and Clinical Immunology.“It is important to recognize the differences in phenotypes between children and adults because different or additional therapeutics may be more suited to children or adults,” Emma Guttman, MD, PhD, vice chair of the department of dermatology at the Icahn School of Medicine at Mount Sinai, told Infectious Diseases in

    Thursday, May 24, 2018 -- by Claudia Mascia, Irene Pozzetto, Blerta Kertusha, Raffaella Marocco, Cosmo Del Borgo, Tiziana Tieghi, Serena Vita, Stefano Savinelli, Marco Iannetta, Vincenzo Vullo, Miriam Lichtner, Claudio Maria Mastroianni Background and aims Measles is an infectious disease that represents a serious public health problem worldwide, being associated with increased susceptibility to secondary infections, especially in the respiratory and gastrointestinal tracts. The aim of this study was to evaluate sCD163 and sCD14 levels in measles virus (MV) infected patients, as markers of immune activation, in order to better understand their role in the pathogenesis of the disease. TNF-α plasma levels were also evaluated. Methods sCD163, sCD14 and TNF-α were measured by ELISA in plasma samples of 27 MV infected patients and 27

    Thursday, May 24, 2018 -- The start-up wants to develop treatments based on two kinds of bacteria linked to the antiseizure effects of the ketogenic diet

    Thursday, May 24, 2018 -- (MedPage Today) -- Steroid-sparing effects demonstrated in small pilot study

    Thursday, May 24, 2018 -- Interview with: Ahmedin Jemal, DVM, PHD Scientific Vice President, Surveillance & Health Services Rsch American Cancer Society, Inc. Atlanta, GA 30303 What is the background for this study? What are the main findings? Response: Historically, lung cancer rates … Continue reading →

    Thursday, May 24, 2018 -- New imaging method may shed light on diabetic retinopathy moconnor Thu, 05/24/2018 - 20:12 Teaser Media Image category Miscellaneous

    Thursday, May 24, 2018 -- In-home rehabilitation, using a telehealth system and supervised by licensed occupational/physical therapists, is an effective means of improving arm motor status in stroke survivors, according to findings presented by University of California, Irvine neurologist Steven C. Cramer, MD, at the recent 2018 European Stroke Organisation Conference in Gothenburg, Sweden.

    Thursday, May 24, 2018 -- The impact of USPSTF recommendations on the incidence and management of prostate cancer have not yet been fully explored.

    Thursday, May 24, 2018 -- Companies to create tests for tissue-agnostic MSI-H and dMMR cancers using Foundation’s next-generation sequencing platform.

    Thursday, May 24, 2018 -- Primary liver tumors and liver metastasis currently represent the leading cause of cancer-related death. Commensal bacteria are important regulators of antitumor immunity, and although the liver is exposed to gut bacteria, their role in antitumor surveillance of liver tumors is poorly understood. We found that altering commensal gut bacteria in mice induced a liver-selective antitumor effect, with an increase of hepatic CXCR6+ natural killer T (NKT) cells and heightened interferon- production upon antigen stimulation. In vivo functional studies showed that NKT cells mediated liver-selective tumor inhibition. NKT cell accumulation was regulated by CXCL16 expression of liver sinusoidal endothelial cells, which was controlled by gut microbiome-mediated primary-to-secondary bile acid conversion. Our study suggests a link between gut bacteria–controlled bile acid

    Thursday, May 24, 2018 -- The discontinuation is voluntary and is not related to product quality, safety or efficacy.

    Thursday, May 24, 2018 -- Dupixent, a drug that already works miracles for people with eczema, has been found to be very effective for treatment of severe asthma. Nothing else does this. Keep this in mind the next time you think that the pharmaceutical industry is not innovative.

    Thursday, May 24, 2018 -- Patients who smoked during treatment for localized prostate cancer faced an increased risk for biochemical recurrence, metastasis and cancer-specific death, according to findings published in JAMA Oncology.“Tobacco smoking is known as a preventable risk factor for the development and mortality of several genitourinary cancers, such as bladder cancer, upper tract urothelial carcinoma and renal cell carcinoma,” Sharokh F. Shariat, MD, department chair and professor of the department of urology at Medical University of Vienna, and colleagues wrote. “In contrast, the effect of

    Thursday, May 24, 2018 -- Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are 2 well-defined entities that diverge in their basic pathogenic mechanisms and clinical evolution but they share epidemiological characteristics, cells of origin, molecular alterations, and clinical features that differ from other lymphoid neoplasms. CLL and MCL are classically considered indolent and aggressive neoplasms, respectively. However, the clinical evolution of both tumors is very heterogeneous, with subsets of patients having stable disease for a long time whereas others require immediate intervention. Both CLL and MCL include 2 major molecular subtypes that seem to derive from antigen-experienced CD5+ B cells that retain a naive or memory-like epigenetic signature and carry a variable load of immunoglobulin heavy-chain variable region somatic mutations from truly

    Thursday, May 24, 2018 -- The development of follicular lymphoma (FL) from a founder B cell with an upregulation of B-cell lymphoma 2 (BCL2), via the t(14;18) translocation, to a proliferating clone, poised to undergo further transformation to an aggressive lymphoma, illustrates the opportunistic Darwinian process of tumorigenesis. Protection against apoptosis allows an innocent cell to persist and divide, with dangerous accumulation of further mutational changes, commonly involving inactivation of chromatin-modifying genes. But this is not all. FL cells reflect normal B cells in relying on expression of surface immunoglobulin. In doing so, they add another supportive mechanism by exploiting the natural process of somatic hypermutation of the IGV genes. Positive selection of motifs for addition of glycan into the antigen-binding sites of virtually

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